Author

A. Fasano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 3 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:proteomics· 4 Research Focus:cell-cell communication· 2 Assay:metabolomics· 2

Frequent Co-Authors

L. M. Yonker· 5 shared A. G. Edlow· 4 shared C. Atyeo· 2 shared E. A. Bordt· 2 shared G. Alter· 2 shared G. Serena· 2 shared K. J. Gray· 2 shared L. L. Shook· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersImmunology

L. M. Yonker

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Author profile →

11 papers

Recent·Most cited

Catalytic bias and redox-driven inactivation of ancestral FeFe hydrogenases from group B

A. Fasano, A. Jacq-Bailly, J. Wozniak, V. Fourmond, C. Leger

This study characterizes two ancestral FeFe hydrogenases, CpIII and MeII, revealing their unique redox-driven inactivation mechanisms and the functional role of the TSCCCP motif.

bioRxiv · Jun 23, 2023Biochemistry

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

B. P. Boribong, T. J. LaSalle, Y. C. Bartsch, F. Ellett, M. E. Loiselle, J. P. Davis, A. L. K. Gonye, S. Hajizadeh, J. Kreuzer, S. Pillai, W. Haas, A. G. Edlow, A. Fasano, G. Alter, D. Irimia, , L. M. Yonker

The paper identifies neutrophil activation and NET formation in MIS-C linked to SARS-CoV-2 immune complexes, differing from acute pediatric COVID-19.

bioRxiv · Dec 18, 2021Immunology

Comprehensive antibody profiling of mRNA vaccination in children

Y. C. Bartsch, K. J. St Denis, P. Kaplonek, J. Kang, E. C. Lam, M. D. Burns, E. J. Farkas, J. Davis, B. Boribong, A. G. Edlow, A. Fasano, W. Shreffler, D. Zavadska, M. Johnson, D. Goldblatt, , A. Galit

This study compares humoral immune responses to mRNA vaccines in children aged 6-11 years, finding that a 100g dose elicits robust and dose-dependent cross-VOC antibody responses with preserved functional immunity.

bioRxiv · Oct 7, 2021 · PreprintImmunology

COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women

C. Atyeo, E. A. Deriso, C. Davis, E. A. Bordt, R. M. De Guzman, L. L. Shook, L. M. Yonker, A. Fasano, B. Akinwunmi, D. A. Lauffenburger, M. A. Elovitz, K. J. Gray, A. G. Edlow, G. J. Alter

This study examines how mRNA vaccines affect Fc-functional antibody profiles in pregnant, lactating, and non-pregnant women, finding delayed kinetics and altered immune responses in pregnant and lactating individuals.

bioRxiv · Apr 4, 2021Immunology

Sexually dimorphic placental responses to maternal SARS-CoV-2 infection

E. A. Bordt, L. L. Shook, C. Atyeo, K. M. Pullen, R. M. De Guzman, M.-C. Meinsohn, M. Chauvin, S. Fischinger, L. J. Yockey, K. James, R. Lima, L. M. Yonker, A. Fasano, S. Brigida, L. M. Bebell, , A. G. Edlow

The paper investigates sex differences in placental responses to maternal SARS-CoV-2 infection, finding sex-specific changes in interferon genes, Fc-receptor expression, and antibody transfer.

bioRxiv · Mar 29, 2021 · PreprintImmunology

A versatile human intestinal organoid-derived epithelial monolayer model for the study of enteric pathogens

K. P. Nickerson, A. Llanos-Chea, L. Ingano, G. Serena, A. Miranda-Ribera, M. Perlman, R. Lima, M. B. Sztein, A. Fasano, S. Senger, C. S. Faherty

This paper develops a human intestinal organoid-derived epithelial monolayer model to study enteric pathogens and finds distinct infection patterns across different gut regions and bacterial strains.

bioRxiv · Nov 24, 2020Microbiology

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

R. A. Porritt, L. Paschold, M. Noval Rivas, M. H. Cheng, L. M. Yonker, H. Chandnani, M. Lopez, D. Simnica, C. Schultheiss, C. Santiskulvong, J. Van Eyk, A. Fasano, I. Bahar, M. Binder, M. Arditi

This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.

bioRxiv · Nov 9, 2020 · PreprintImmunology

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

B. D. Needham, M. D. Adame, G. Serena, D. R. Rose, G. M. Preston, M. C. Conrad, A. S. Campbell, D. H. Donabedian, A. Fasano, P. Ashwood, S. K. Mazmanian

The paper analyzes plasma and fecal metabolite profiles in children with ASD and typically developing controls to identify metabolic differences and their associations with clinical behaviors and GI dysfunction.

bioRxiv · May 17, 2020Biochemistry

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

R. E. N. van der Welle, R. Jobling, C. Burns, P. Sanza, C. ten Brink, A. Fasano, L. Chen, F. J. Zwartkruis, S. Zwakenberg, E. F. Griffin, J. van der Beek, T. Veenendaal, N. Liv, S. Blaser, C. Sepulveda, , J. Klumperman

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

bioRxiv · Dec 18, 2019 · PreprintCell Biology

Molecular structure and function of myelin protein P0 in membrane stacking

A. Raasakka, S. Ruskamo, J. Kowal, H. Han, A. Baumann, M. Myllykoski, A. Fasano, R. Rossano, P. Riccio, J. Buerck, A. S. Ulrich, H. Stahlberg, P. Kursula

This study characterizes the molecular structure and function of myelin protein P0, showing how its extracellular domains stack lipid membranes and stabilize the intraperiod line in peripheral myelin.

bioRxiv · Aug 19, 2018Biochemistry

Microbial Biomarkers of Intestinal Barrier Maturation in Preterm Infants

B. Ma, E. McComb, P. Gajer, H. Yang, M. Humphrys, A. C. Okogbule-Wonodi, A. Fasano, J. Ravel, R. M. Viscardi

This study identifies microbial biomarkers associated with intestinal barrier maturation in preterm infants, linking Clostridiales abundance and breastfeeding to reduced gut permeability.

bioRxiv · May 9, 2018Microbiology