M. H. Cheng

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

Structural mechanisms for VMAT2 inhibition by tetrabenazine

This study reports the cryo-EM structure of VMAT2 bound to tetrabenazine, revealing its inhibition mechanism and conformational dynamics.

Structural basis of CMKLR1 signaling induced by chemerin9

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro

This paper shows that an anti-SEB monoclonal antibody inhibits SARS-CoV-2 entry by blocking protease access to the Spike protein's cleavage site.

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome

This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.

An insertion unique to SARS-CoV-2 exhibits superantigenic character strengthened by recent mutations

The paper identifies a SARS-CoV-2 spike protein motif with superantigen-like properties that may contribute to MIS-C and cytokine storms in COVID-19 patients.