H. E. Gaub

Effects of Variants of Concern Mutations on the Force-Stability of the SARS-CoV-2:ACE2 Interface and Virus Transmissibility

This study examines how mutations in SARS-CoV-2 variants affect the force-stability of the SARS-CoV-2:ACE2 interface and virus transmissibility.

A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 Interactions

This paper introduces a tethered ligand assay to study SARS-CoV-2:ACE2 interactions under mechanical force, showing higher stability and lower dissociation rates compared to SARS-CoV-1.

Kinetic Interval Measurement: A Tool to Characterize Thermal Reversion Dynamics of Light-switchable Fluorescent Proteins

The paper introduces KIM, a method to measure thermal reversion dynamics of light-switchable proteins using a microplate reader, showing its ability to determine reversion half-life and sensitivity to temperature and imidazole concentration.

A Tethered Ligand Assay to Probe the SARS-CoV-2 ACE2 Interaction under Constant Force

This paper introduces a tethered ligand assay to study SARS-CoV-2 ACE2 interactions under constant force and finds that the interaction is more mechanically stable and has a slower off-rate compared to SARS-CoV-1.

Is mechanical receptor ligand dissociation driven by unfolding or unbinding?

The paper investigates whether mechanical dissociation of protein-protein interactions involves unfolding or unbinding, finding that one or both partners can unfold during dissociation.