Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrils
S. Dhakal, C. E. Wyant, H. E. George, S. E. Morgan, V. Rangachari
This study investigates the synergistic interaction between TDP-43's prion-like domain and α-synuclein, showing they form toxic hybrid fibrils with increased cytotoxicity.
bioRxiv · Dec 12, 2020Biophysics