Author

H. E. Jacobs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. Pilzecker· 1 shared C. J. van Noesel· 1 shared J. E. Guikema· 1 shared M. Bahjat· 1 shared M. Stratigopoulou· 1 shared R. J. Bende· 1 shared S. Mobach· 1 shared T. P. van Dam· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperImmunology

B. Pilzecker

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1 paper

Recent·Most cited

DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair

M. Bahjat, M. Stratigopoulou, B. Pilzecker, T. P. van Dam, S. Mobach, R. J. Bende, C. J. van Noesel, H. E. Jacobs, J. E. Guikema

The paper shows that DNA polymerase β degradation in GC B cells leads to mutagenic non-canonical mismatch repair, promoting A:T mutations during somatic hypermutation.

bioRxiv · Jan 30, 2020 · PreprintImmunology