Author

C. J. van Noesel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. E. Guikema· 2 shared R. J. Bende· 2 shared B. Pilzecker· 1 shared C. Maas· 1 shared E. E. Eldering· 1 shared G. de Wilde· 1 shared H. E. Jacobs· 1 shared M. Bahjat· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

J. E. Guikema

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJan 30, 2020

DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair

M. Bahjat, M. Stratigopoulou, B. Pilzecker…·J. E. Guikema

The paper shows that DNA polymerase β degradation in GC B cells leads to mutagenic non-canonical mismatch repair, promoting A:T mutations during somatic hypermutation.

DOI 10.1101/2020.01.30.926964

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivOct 24, 2019

Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma

T. A. Bloedjes, G. de Wilde, C. Maas…·J. E. Guikema

This study shows that AKT inhibition in multiple myeloma activates FOXO and GSK3, leading to MCL1 reduction and cell death, suggesting potential for combination therapies.

DOI 10.1182/bloodadvances.2019001393

humanbulk RNA-seq

𝕏 PostBluesky