Author

J. E. Guikema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

R. J. Bende· 3 shared C. J. van Noesel· 2 shared M. Stratigopoulou· 2 shared A. H. M. Bouts· 1 shared A. Pelissier· 1 shared B. Pilzecker· 1 shared C. J. M. van Noesel· 1 shared C. Maas· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersEvolutionary Biology

R. J. Bende

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Levamisole suppresses activation and proliferation of human T cells by the induction of a p53-dependent DNA damage response

G. H. Khan, F. Veltkamp, M. Scheper, R. A. Hoebe, N. Claessen, L. Butter, A. H. M. Bouts, S. Florquin, J. E. Guikema

bioRxiv · May 8, 2023Immunology

Convergent Evolution and B-Cell Recirculation in Germinal Centers in a Human Lymph Node

A. Pelissier, M. Stratigopoulou, N. Donner, E. Dimitriadis, R. J. Bende, J. E. Guikema, M. R. Martinez, C. J. M. van Noesel

The paper analyzes B-cell clonal diversity and evolution in human germinal centers using LCM and Rep-seq, finding convergent evolution and shared antigen responses across GCs.

bioRxiv · Nov 9, 2022Evolutionary Biology

DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair

M. Bahjat, M. Stratigopoulou, B. Pilzecker, T. P. van Dam, S. Mobach, R. J. Bende, C. J. van Noesel, H. E. Jacobs, J. E. Guikema

The paper shows that DNA polymerase β degradation in GC B cells leads to mutagenic non-canonical mismatch repair, promoting A:T mutations during somatic hypermutation.

bioRxiv · Jan 30, 2020 · PreprintImmunology

Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma

T. A. Bloedjes, G. de Wilde, C. Maas, E. E. Eldering, R. J. Bende, C. J. van Noesel, S. T. Pals, M. Spaargaren, J. E. Guikema

This study shows that AKT inhibition in multiple myeloma activates FOXO and GSK3, leading to MCL1 reduction and cell death, suggesting potential for combination therapies.

bioRxiv · Oct 24, 2019Cancer Biology