Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation
K. B. Leszczynska, M. Dzwigonska, H. Estephan, J. Moehlenbrink, E. Bowler, A. J. Giaccia, J. Mieczkowski, B. Kaminska, E. M. Hammond
The paper shows hypoxia reduces DDX5 expression by decreasing chromatin accessibility and post-translational targeting, which limits R-loop accumulation in cancer cells.
bioRxiv · Apr 30, 2022Cancer Biology