Author

E. M. Hammond

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Cerutti· 1 shared A. Cicconi· 1 shared A. Galbiati· 1 shared A. J. Giaccia· 1 shared B. Kaminska· 1 shared D. Ebner· 1 shared D. Grande· 1 shared D. Piscitello· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Cerutti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

G. Rodriguez-Berriguete, M. Ranzani, R. Prevo, R. Puliyadi, N. Machado, H. R. Bolland, V. Millar, D. Ebner, M. Boursier, A. Cerutti, A. Cicconi, A. Galbiati, D. Grande, V. Grinkevich, J. Majithiya, , G. S. Higgins

This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.

bioRxiv · Sep 27, 2022Cancer Biology

Hypoxia-mediated regulation of DDX5 through decreased chromatin accessibility and post-translational targeting restricts R-loop accumulation

K. B. Leszczynska, M. Dzwigonska, H. Estephan, J. Moehlenbrink, E. Bowler, A. J. Giaccia, J. Mieczkowski, B. Kaminska, E. M. Hammond

The paper shows hypoxia reduces DDX5 expression by decreasing chromatin accessibility and post-translational targeting, which limits R-loop accumulation in cancer cells.

bioRxiv · Apr 30, 2022Cancer Biology

A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia

G. L. Celora, P. K. Maini, H. M. Byrne, E. M. Hammond, S. B. Bader, J. Pitt-Francis

This paper develops a DNA-structured mathematical model to predict how cyclic hypoxia affects cell-cycle progression, showing that prolonged re-oxygenation slows proliferation while short cycles inhibit it.

bioRxiv · Aug 9, 2021Cancer Biology

Hypoxia-induced SETX links replication stress with the unfolded protein response

S. Ramachandran, T. Ma, N. Ng, I. Foskolou, M.-S. Hwang, P. Victori, W.-C. Cheng, F. M. Buffa, K. Leszczynska, N. Gromak, E. M. Hammond

This study shows hypoxia induces SETX, which protects cells from DNA damage by linking replication stress and the unfolded protein response.

bioRxiv · May 24, 2020Cancer Biology