Author

H. F. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 7 Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:imaging· 9 Research Focus:cell type annotation· 5 Organism:human· 5 Approach:experimental assay· 4 Approach:statistical model· 4 Approach:microscopy & imaging analysis· 3 Organism:non-human primate· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

I. Rubinoff· 5 shared C. Sun· 4 shared R. Fang· 4 shared B. Brenner· 3 shared Y. Wang· 3 shared Y. Zhang· 3 shared D. A. Miller· 2 shared G. Wollstein· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersBioengineering

I. Rubinoff

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10 papers

Recent·Most cited

Physically informed Monte Carlo simulation of dual-wedge prism-based spectroscopic single-molecule localization microscopy

W.-H. Yeo, C. Sun, H. F. Zhang

The paper develops a Monte Carlo simulation model to predict and optimize the performance of dual-wedge prism-based spectroscopic single-molecule localization microscopy systems.

bioRxiv · May 18, 2023Bioengineering

Multiscale imaging of corneal endothelium damage and effects of Rho Kinase inhibitor application in mouse models of acute ocular hypertension

Z. Cai, Y. Zhang, R. Fang, B. Brenner, J. Kweon, C. Sun, J. Goldberg, H. F. Zhang

The paper uses multiscale imaging to study corneal endothelium damage in mouse models, finding that Rho Kinase inhibitors reduce fully-distorted tight junctions under acute ocular hypertension.

bioRxiv · May 18, 2023Biophysics

Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles

D. Miller, M. Grannonico, M. Liu, E. Savier, K. McHaney, A. Erisir, P. Netland, X. Liu, H. F. Zhang

This study uses vis-OCTF and TSA to image tree shrew retinal ganglion cell axon bundles in vivo, quantifying their dimensions and showing changes with distance from the optic nerve head.

bioRxiv · May 16, 2023Bioengineering

Quantify nanoscopic alterations associated with mitochondrial dysfunctions using three-dimensional single-molecule localization microscopy

B. Brenner, Y. Zhang, J. Kweon, R. Fang, N. Sheibani, S. X. Zhang, C. Sun, H. F. Zhang

This paper introduces a quantitative method to analyze mitochondrial morphology using 3D single-molecule localization microscopy, validated with simulated data and tested on altered mitochondria.

bioRxiv · May 10, 2023 · PreprintBiophysics

Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography

R. Fang, I. Rubinoff, H. F. Zhang

The paper investigates how multiple forward scattering affects the measured scattering coefficient of whole blood in visible-light OCT, introducing a scaling factor to correct for this effect.

bioRxiv · Mar 20, 2022 · PreprintBioengineering

Balanced-detection visible-light optical coherence tomography

I. Rubinoff, D. A. Miller, R. Kuranov, Y. Wang, R. Fang, N. J. Volpe, H. F. Zhang

This paper introduces balanced-detection visible-light OCT to improve sensitivity and reduce noise, enabling clearer retinal imaging in healthy volunteers.

bioRxiv · Jun 8, 2021 · PreprintBioengineering

Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry

I. Rubinoff, R. V. Kuranov, Z. Ghassabi, Y. Wang, L. Beckmann, D. A. Miller, B. Tayebi, G. Wollstein, H. Ishikawa, J. S. Schuman, H. F. Zhang

This paper develops and validates an adaptive spectroscopic vis-OCT method to improve retinal oxygen saturation measurements by removing spectral contaminants, showing accuracy in both ex vivo and human retinal vessels.

bioRxiv · May 28, 2021 · PreprintBioengineering

In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

Z. Ghassabi, R. Kuranov, M. Wu, B. T. Tayebi, Y. Wang, I. Rubinoff, X. Liu, G. Wollstein, J. S. Schuman, H. F. Zhang, H. Ishikawa

This study uses visible-light OCT to analyze IPL sublayers in glaucoma and healthy subjects, finding that middle sublayer thinning is most significant in glaucoma.

bioRxiv · Jan 8, 2021 · PreprintBioengineering

Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography

I. Rubinoff, R. V. Kuranov, H. F. Zhang

This study identifies and addresses a spectrally-dependent background bias in visible-light OCT, improving accuracy for retinal oximetry.

bioRxiv · Sep 13, 2020Bioengineering

Symmetrically-dispersed spectroscopic single-molecule localization microscopy

K.-H. Song, Y. Zhang, B. Brenner, C. Sun, H. F. Zhang

This paper introduces SDsSMLM, a spectroscopic single-molecule localization microscopy technique that improves spatial and spectral precision by symmetrically dispersing photons.

bioRxiv · Dec 14, 2019Biophysics