H. Ishikawa

Phosphodiesterase 3 inhibitors boost bone outgrowth

This study shows that PDE3 inhibitors enhance bone growth by increasing Ca2+ influx through TRPM7 channels in chondrocytes, suggesting potential repositioning for short stature syndromes.

In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

Testing the ion-current model for flagellar length sensing and IFT regulation

This study tests the ion-current model for flagellar length sensing by measuring Ca2+ levels and IFT injection in Chlamydomonas, finding no support for the model's predictions.

Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

The paper identifies baseline AP-1 gene expression and gut microbial fucose/rhamnose degradation as factors negatively correlated with BNT162b2 mRNA vaccine-induced T-cell responses.

A nano-liquid hub integrating growth and immune-evasion signaling to promote cell survival

The paper identifies GEM, a nano-liquid hub that integrates growth and immune-evasion signaling to enhance cell survival in mice.

The short flagella 1 (SHF1) gene in Chlamydomonas encodes a Crescerin TOG-domain protein required for late stages of flagellar growth.

The paper identifies SHF1 as a Crescerin TOG-domain protein in Chlamydomonas required for flagellar growth, showing it enhances tubulin polymerization and compensates for decreasing IFT cargo.

Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake

The paper analyzes glucose, fructose, and sucrose contents in Japanese beverages to assess actual sugar intake, finding discrepancies between measured sugar and labeled carbohydrate content.

Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry

This paper develops and validates an adaptive spectroscopic vis-OCT method to improve retinal oxygen saturation measurements by removing spectral contaminants, showing accuracy in both ex vivo and human retinal vessels.

In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

This study uses visible-light OCT to analyze IPL sublayers in glaucoma and healthy subjects, finding that middle sublayer thinning is most significant in glaucoma.

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.

Association between the extent of DNA methylation at the CpG sites of HIF3A and parameters of obesity in the general Japanese population

The paper examines the association between DNA methylation at HIF3A CpG sites and obesity parameters in Japanese women, finding a link between methylation at cg27146050 and visceral fat thickness, BMI, and body fat percentage.

Analysis of Biological Noise in an Organelle Size Control System

The paper analyzes biological noise in flagellar length control in Chlamydomonas, showing cell-to-cell and within-cell variation and linking it to homeostatic mechanisms and tubulin dynamics.

Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier.

This study identifies that Zika virus infects pericytes in the choroid plexus and crosses the blood-CSF barrier to enter the CNS, with CSF neutralization reducing brain infection.

A survey of vaccine-induced measles IgG antibody titer and the verification of changes in temporal differences of measles vaccination in young adults

This study examines measles IgG antibody titers in young adults and finds that antibody levels correlate with medical history and time since last vaccination, suggesting the need for periodic measles vaccination.