H. G. Franquelim

DNA Origami Vesicle Sensors with Triggered Cargo Transfer

The paper describes a DNA origami-based biosensor that detects lipid vesicles through smFRET and enables targeted cargo transfer to vesicles.

Nanoscale structural response of biomimetic cell membranes to controlled dehydration.

This study investigates how lipid membranes reorganize structurally at the nanoscale under varying hydration conditions, revealing reversible changes in lipid phase behavior and physical properties.

Structural Diversity of Photoswitchable Sphingolipids for Optodynamic Control of Lipid Raft Microdomains

This study develops photoswitchable sphingolipids to control lipid raft microdomains in model membranes using light-induced isomerization.

DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity

The paper develops DNA origami-based voltage sensors with single-molecule sensitivity, showing a 5% FRET change for 100 mV transmembrane potential shifts.

Hydration layer of only few molecules controls lipid mobility in biomimetic membranes

This study shows that a hydration layer of 6-7 water molecules controls lipid mobility in biomimetic membranes, with significant effects on diffusion and activation energy.