T. Schroeder

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

This study examines the impact of SARS-CoV-2 infection on intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients, finding associations between specific microbial changes and disease severity.

DNA Origami Vesicle Sensors with Triggered Cargo Transfer

The paper describes a DNA origami-based biosensor that detects lipid vesicles through smFRET and enables targeted cargo transfer to vesicles.

Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika-virus infected macaques

This study links reduced short-chain fatty acid levels with elevated inflammation in Zika-virus infected macaques, suggesting microbial dysfunction contributes to CNS and systemic inflammation.

IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells

This study shows IL-1β promotes MPN initiation by enhancing early clonal expansion of JAK2-mutant HSCs in a mouse model.

Super-Resolved FRET and Co-Tracking in pMINFLUX

This paper introduces two methods in pMINFLUX to enable nanometer-precise co-localized tracking of fluorophores, bridging the resolution gap between smFRET and co-tracking.

Asymmetric cell division safeguards memory CD8 T cell development

This study shows that asymmetric cell division supports memory CD8 T cell development under strong TCR stimulation but not weak stimulation.

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

Heritable changes in division speed accompany the diversification of singleT cell fate

This study tracks division speed and lineage fate in single CD8+ T cells during clonal expansion, revealing a burst phase of homogeneous division followed by diversification into effector and memory branches.

Open-source personal pipetting robots with live-cell incubation and microscopy compatibility

The paper introduces an open-source personal pipetting robot compatible with live-cell incubation and microscopy, designed for non-specialists to automate experiments.

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

Pre-Settlement Forests of Southwest Washington: Witness Statements

This paper reconstructs pre-settlement forest composition and distribution in Southwest Washington using witness trees from historical surveys.

DNA origami-based single-molecule force spectroscopy unravels the molecular basis of RNA Polymerase III pre-initiation complex stability

The paper uses DNA origami force clamps to study how force affects initiation complex stability in RNA polymerase II and III systems, revealing Bdp1's critical role in RNAP III stability.

Pre-Settlement Forests around Puget Sound: Eyewitness Evidence

The paper uses witness trees from historical surveys to analyze pre-settlement forest composition and successional patterns around Puget Sound, revealing local diversity and challenging assumptions about climax species.

An incremental training method with automated, extendible T-maze for training spatial behavioral tasks in rodents

This paper introduces an automated T-maze system for training spatial tasks in rodents, demonstrating its effectiveness in a binary forced-choice task.

The Object Space Task for mice and rats

This study introduces a new behavioral task for rodents to investigate memory formation, showing that both mice and rats can accumulate information across trials and form long-term abstracted memories.