Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease
P. Fang, H. Espey, L. Yu, G. Agirman, K. Li, Y. Deng, J. Lee, H. Hncir, A. P. Arnold, E. Y. Hsiao
This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.
bioRxiv · Nov 30, 2022 · PreprintPhysiology