E. Y. Hsiao

The maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavioral impairment in mice

This study shows that maternal microbiome alterations during protein undernutrition in mice modify offspring neurobehavioral impairments, with microbiome-targeted interventions offering potential mitigation.

Complex carbohydrate utilization by gut bacteria modulates host food preference

This study shows that gut bacteria ferment specific fructans, influencing host preference for non-fermentable fructan diets through neuronal activation in the hypothalamus.

Turicibacter strains differentially modify bile acids and host lipids

The paper characterizes Turicibacter strains' bile acid and lipid-modifying capabilities, showing strain-specific effects on host metabolism and lipid profiles.

Ketogenic diet therapy for pediatric epilepsy is associated with alterations in the human gut microbiome that confer seizure resistance in mice

This study shows that the ketogenic diet alters the gut microbiome in children with epilepsy, and transferring these microbes to mice increases seizure resistance.

The maternal microbiome promotes placental development in mice

This study shows that the maternal gut microbiome supports placental development in mice by modulating metabolites and promoting vascularization.

Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.