Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by PU.1
J. Ungerback, H. Hosokawa, X. Wang, T. Strid, B. A. Williams, M. Sigvardsson, E. V. Rothenberg
This study investigates PU.1's pioneering activity in early T-cell development, showing its ability to bind and open closed chromatin sites despite lacking collaborators, and its role in regulating gene accessibility and transcription.
bioRxiv · May 25, 2018Immunology