B. A. Williams

Human hnRNPA1 reorganizes telomere-bound Replication Protein A

The paper shows hnRNPA1 remodels RPA bound to telomeric ssDNA, forming a ternary complex regulated by TERRA.

The global rarity of intact coastal regions

The paper assesses global coastal regions' anthropogenic pressures by integrating human footprint and marine impact maps, finding that most are heavily impacted and protected areas are often under high pressure.

The minimum land area requiring conservation attention to safeguard biodiversity

The paper estimates that 64 million km2 of terrestrial land requires conservation attention to safeguard biodiversity, with potential losses of 1.3 million km2 by 2030 under intensive land-use scenarios.

Change in terrestrial human footprint drives continued loss of intact ecosystems

The paper maps changes in the terrestrial human footprint from 2000 to 2013, showing a significant loss of intact ecosystems, particularly in tropical and subtropical regions.

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by PU.1

This study investigates PU.1's pioneering activity in early T-cell development, showing its ability to bind and open closed chromatin sites despite lacking collaborators, and its role in regulating gene accessibility and transcription.