Author

E. V. Rothenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Shin· 2 shared F. Gao· 2 shared W. Zhou· 2 shared B. A. Williams· 1 shared C. Liu· 1 shared E. C. K. Wan· 1 shared E. E. West· 1 shared H. Hosokawa· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

B. Shin

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4 papers

Recent·Most cited

Runx factors launch T-cell and innate lymphoid programs via direct and gene network-based mechanisms

B. Shin, W. Zhou, J. Wang, F. Gao, E. V. Rothenberg

The paper shows Runx factors regulate T-cell and innate lymphoid programs through dynamic binding and gene network interactions during early development.

bioRxiv · Nov 18, 2022Immunology

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

R. Spolski, P. Li, V. Chandra, B. Shin, C. Liu, J. Oh, M. Ren, Y. Enomoto, E. E. West, S. Christensen, E. C. K. Wan, M. Ge, J.-X. Lin, P. Vijayanand, E. V. Rothenberg, W. J. Leonard

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

bioRxiv · Nov 18, 2022 · PreprintImmunology

Single-cell perturbation dissects transcription factor control of progression speed and trajectory choice in early T-cell development

W. Zhou, F. Gao, M. Romero-Wolf, S. Jo, E. V. Rothenberg

The paper uses single-cell CRISPR perturbation to study how transcription factors influence progression speed and trajectory choice in early T-cell development.

bioRxiv · Sep 3, 2021Immunology

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by PU.1

J. Ungerback, H. Hosokawa, X. Wang, T. Strid, B. A. Williams, M. Sigvardsson, E. V. Rothenberg

This study investigates PU.1's pioneering activity in early T-cell development, showing its ability to bind and open closed chromatin sites despite lacking collaborators, and its role in regulating gene accessibility and transcription.

bioRxiv · May 25, 2018Immunology