The Consequences of Egg Adaptation in the H3N2 Component to the Immunogenicity of Live Attenuated Influenza Vaccine
D. H. Goldhill, B. Lindsey, R. Kugathasan, Z. F. Garza, Y. J. Jagne, H. J. Sallah, G. Goderski, S. van Tol, K. Höschler, A. Meijer, W. S. Barclay, T. de Silva
This study examines how egg adaptation of the H3N2 influenza vaccine strain affects antibody responses in children, finding higher seroconversion rates to the adapted strain but differential mucosal IgA responses based on prior serostatus.
bioRxiv · Nov 12, 2019 · PreprintImmunology