Author

H. J. Sosa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. B. Asenjo· 2 shared A. Gennerich· 1 shared D. F. J. Arginteanu· 1 shared G.-Y. Chen· 1 shared J. Mascaro· 1 shared L. Rao· 1 shared M. P. M. H. Benoit· 1 shared W. O. Hancock· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. B. Asenjo

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2 papers

Recent·Most cited

Cryo-EM Unveils the Processivity Mechanism of Kinesin KIF1A and the Impact of its Pathogenic Variant P305L

M. P. M. H. Benoit, L. Rao, A. B. Asenjo, A. Gennerich, H. J. Sosa

The paper presents high-resolution cryo-EM structures of KIF1A-microtubule complexes, revealing the mechanism of processivity and the impact of the P305L mutation on microtubule binding.

bioRxiv · Feb 2, 2023 · PreprintBiochemistry

Kinesin-5 promotes microtubule nucleation and assembly by stabilizing a lattice-competent conformation of tubulin

G.-Y. Chen, A. B. Asenjo, Y. Chen, J. Mascaro, D. F. J. Arginteanu, H. J. Sosa, W. O. Hancock

This study identifies Eg5 as a microtubule polymerase that promotes microtubule growth by inducing a curved-to-straight transition in tubulin.

bioRxiv · Jan 14, 2019Biophysics