A role of cellular translation regulation associated with toxic Huntingtin protein
H. Joag, V. Ghatpande, M. Sarkar, A. Raina, M. Desai, M. Shinde, T. Bose, A. Majumdar
This study shows that pathogenic Huntingtin protein sequesters the translation regulator Orb2, leading to protein synthesis deficits and lethality, suggesting translation dysfunction as a contributor to Huntington's disease.
bioRxiv · Jul 1, 2019Cell Biology