A. Majumdar

Niacinamide enhances cathelicidin mediated SARS-CoV-2 membrane disruption

This study shows niacinamide enhances LL37's ability to disrupt SARS-CoV-2 membranes, suggesting it could improve AMP-based therapies for COVID-19.

Pathogenic aggregates alter actin organization and cellular viscosity resulting in stalled clathrin mediated endocytosis

This study shows that pathogenic protein aggregates disrupt actin organization and cellular viscosity, impairing clathrin-mediated endocytosis in neurodegenerative conditions.

Pyrroloquinoline Quinone inhibits PCSK9, augments LDLR recycling and enhances the effect of atorvastatin

This study investigates how PQQ and atorvastatin affect PCSK9 expression in rats fed a high-fat diet, showing reduced lipid levels and improved liver function.

The mechanism of RNA capping by SARS-CoV-2

This study reveals how SARS-CoV-2 caps its RNA genome through an unconventional mechanism involving RNAylation and methyltransferase activity, identifying potential antiviral targets.

Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions

This study investigates cluster formation in subsaturated solutions of RNA binding proteins with prion-like domains and finds that cluster formation and phase separation are coupled through sequence-specific interactions.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

The ASCC2 CUE domain contacts adjacent ubiquitins to recognize K63-linked polyubiquitin

This study shows that the ASCC2 CUE domain binds K63-linked diubiquitin by interacting with both ubiquitins, with unique contacts to the proximal ubiquitin that are critical for ASCC2 recruitment during DNA alkylation response.

Nup358 regulates remodelling of ER-mitochondrial contact sites and autophagy

This study shows that Nup358 regulates ER-mitochondria contact sites dynamics and autophagy by modulating mTORC2/Akt signaling and Ca2+ release.

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

This study shows that TPP1 promotes fibrillar β-amyloid degradation in microglia and that reducing TPP1 increases amyloid plaque burden in an AD mouse model.

The properties of buried ion pairs are governed by the propensity of proteins to reorganize

This study investigates how proteins accommodate buried ion pairs by reorganizing their structure, showing that structural reorganization reduces the energetic penalty of burying charges.

Electrostatic effects in proteins are governed by pH-redistribution of the conformational ensemble

This study shows that buried ionizable residues in proteins influence conformational changes through pH-driven redistribution, not just their local environment.

A role of cellular translation regulation associated with toxic Huntingtin protein

This study shows that pathogenic Huntingtin protein sequesters the translation regulator Orb2, leading to protein synthesis deficits and lethality, suggesting translation dysfunction as a contributor to Huntington's disease.

Liquid-Liquid Phase Separation is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

This study shows that liquid-liquid phase separation of tau, an intrinsically disordered protein, is driven by conformational unwinding, solvation, and torsional fluctuations.