Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors
G. J. M. Cowan, K. Miles, L. Capitani, S. S. B. Giguere, H. Johnsson, C. Goodyear, I. B. McInnes, Scottish Early Rheumatoid Arthritis Inception cohort Investigators, S. Breusch, D. Gray, M. Gray
This study identifies that RA patients have a higher proportion of poorly mutated, polyclonal IgG+ve BCRs in peripheral blood and synovium, suggesting a role in autoimmune inflammation.
bioRxiv · Sep 18, 2019 · PreprintImmunology