Author

I. B. McInnes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Arthur· 1 shared A. Elmesmari· 1 shared B. Tolusso· 1 shared C. Goodyear· 1 shared C. McSharry· 1 shared D. Gray· 1 shared D. Martin· 1 shared D. Somma· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

A. Arthur

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4 papers

Recent·Most cited

Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration

G. R. Meehan, I. B. McInnes, J. M. Brewer, P. Garside

This study shows that timing of antigen administration affects disease outcome in an animal model of inflammatory arthritis, with pre-challenge administration reducing pathology and post-challenge administration exacerbating it.

bioRxiv · Jan 7, 2022Immunology

COVID-19 and Rheumatoid Arthritis share myeloid pathogenic and resolving pathways

L. MacDonald, T. D. Otto, A. Elmesmari, B. Tolusso, D. Somma, C. McSharry, E. Gremese, I. B. McInnes, S. Alivernini, M. Kurowska-Stolarska

This study identifies shared myeloid pathways between COVID-19 pneumonitis and RA synovitis, highlighting MerTK as a therapeutic target for both conditions.

bioRxiv · Jul 26, 2020 · PreprintImmunology

Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors

G. J. M. Cowan, K. Miles, L. Capitani, S. S. B. Giguere, H. Johnsson, C. Goodyear, I. B. McInnes, Scottish Early Rheumatoid Arthritis Inception cohort Investigators, S. Breusch, D. Gray, M. Gray

This study identifies that RA patients have a higher proportion of poorly mutated, polyclonal IgG+ve BCRs in peripheral blood and synovium, suggesting a role in autoimmune inflammation.

bioRxiv · Sep 18, 2019 · PreprintImmunology

Stromal fibroblast activation and inflammation in frozen shoulder

M. Akbar, M. McLean, E. Garcia-Melchor, L. A. Crowe, P. McMillan, U. G. Fazzi, D. Martin, A. Arthur, J. H. Reilly, I. B. McInnes, N. L. Millar

This study investigates stromal fibroblast activation and inflammation in frozen shoulder, finding increased expression of activation markers and inflammatory cytokines in diseased tissue.

bioRxiv · Oct 26, 2018 · PreprintImmunology