TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1
J. Zhou, N. L. Rasmussen, H. L. Olsvik, V. Akimov, Z. Hu, G. Evjen, B. Blagoev, T. Lamark, T. Johansen, J. Dengjel
The paper shows TBK1 phosphorylates TNIP1, activating its LIR-dependent autophagy-mediated degradation, which promotes pro-inflammatory gene expression.
bioRxiv · Mar 2, 2022Cell Biology