TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery
B. Saha, H. Olsvik, G. L. Williams, S. Oh, G. Evjen, E. Sjottem, M. A. Mandell
The paper shows TRIM5 ubiquitinates TBK1 to assemble mitophagy machinery on damaged mitochondria, essential for both Parkin-dependent and independent mitophagy.
bioRxiv · Oct 19, 2023Cell Biology