Spi-C and PU.1 counterregulate Rag1 and Igκ transcription to effect immunoglobulin kappa recombination in small pre-B cells
L. S. Xu, J. T. Zhu, H. L. Raczkowski, C. R. Batista, R. P. DeKoter
bioRxiv · Dec 28, 2022 · PreprintImmunology
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L. S. Xu, J. T. Zhu, H. L. Raczkowski, C. R. Batista, R. P. DeKoter
bioRxiv · Dec 28, 2022 · PreprintImmunology
H. L. Raczkowski, L. S. Xu, W. C. Wang, R. P. DeKoter
The paper investigates how external signals regulate Spi-C expression in B cells, showing that factors like lipopolysaccharide and cytokines reduce Spic levels, while some treatments partially prevent this downregulation.
bioRxiv · Aug 25, 2021Immunology