H. L. Scott

Optimization of cryo-electron microscopy for quantitative analysis of lipid bilayers

This paper optimizes cryo-EM parameters and analysis methods to accurately measure bilayer thickness and detect lateral heterogeneity in lipid membranes.

Lactoferricins access the cytosol of Escherichia coli within few seconds

This study shows lactoferricin-derived AMPs rapidly enter E. coli cytosol within seconds, leading to metabolic shutdown, with membrane damage being a secondary effect.

Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy

This paper uses cryoEM to directly image nanodomains in biomimetic and biological membranes without extrinsic probes, revealing structural differences at sub-angstrom resolution.

On the mechanism of bilayer separation by extrusion; or, why your large unilamellar vesicles are not really unilamellar

This paper shows extruded vesicles are often multilamellar, not unilamellar, and identifies factors that influence lamellarity.

PS membrane asymmetry influences the folding and insertion of a transmembrane helix

This study investigates how PS membrane asymmetry affects pHLIP topology and insertion, finding that lipid asymmetry influences membrane protein behavior.