H. Marcotte

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Vaccination with Helicobacter pylori attachment proteins protects against gastric cancer

This study shows that vaccination with H. pylori attachment protein BabA induces blocking antibodies that reduce gastric inflammation and prevent gastric cancer in mice.

Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease

The paper shows that antibodies blocking H. pylori attachment reduce chronic inflammation and duodenal ulcer risk by mimicking BabA's binding to ABO glycans.

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

The paper identifies broadly cross-reactive neutralizing antibodies against SARS-CoV-2 variants using coldspot-guided antibody discovery.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

Inducible Plasmid Self-Destruction (IPSD) assisted genome engineering in lactobacilli and bifidobacteria

This paper introduces IPSD, a genome engineering method for lactobacilli and bifidobacteria using inducible plasmid self-destruction to enable gene knock-out and knock-in.