Author

I. Cassaniti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Assay:proteomics· 7 Organism:mouse· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Baldanti· 9 shared E. Percivalle· 7 shared A. Ferrari· 5 shared A. Gambotto· 5 shared E. Kim· 5 shared J. C. Sammartino· 5 shared M. S. Khan· 5 shared S. Huang· 5 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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9 shared papersImmunology

F. Baldanti

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Second Boost of Omicron SARS-CoV-2 S1 Subunit Vaccine Induced Broad Humoral Immune Responses in Elderly Mice

E. Kim, M. S. Khan, A. Ferrari, S. Huang, T. W. Kenniston, I. Cassaniti, F. Baldanti, A. Gambotto

This study shows that a second booster dose of an Omicron S1 subunit vaccine enhances broad humoral immunity and cross-neutralizing antibodies in elderly mice.

bioRxiv · Feb 5, 2024 · PreprintImmunology

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

H. Marcotte, Y. Cao, F. Zuo, L. Simonelli, J. C. Sammartino, M. Pedotti, R. Sun, I. Cassaniti, M. Hagbom, A. Piralla, J. Yang, L. Du, E. Percivalle, F. Bertoglio, M. Schubert, , Q. Pan-Hammarstrom

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Proceedings of the National Academy of Sciences · Jan 9, 2024Peer-reviewedMicrobiology

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

E. Kim, J. Shin, A. Ferrari, S. Huang, E. An, D. Han, M. S. Khan, T. W. Kenniston, I. Cassaniti, F. Baldanti, D. Jeong, A. Gambotto

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

bioRxiv · Oct 5, 2023Immunology

Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers

M. S. Khan, E. Kim, Q. Le Hingrat, A. Kleinman, A. Ferrari, J. C. Sammartino, E. Percivalle, C. Xu, S. Huang, T. W. Kenniston, I. Cassaniti, F. Baldanti, I. Pandrea, A. Gambotto, C. Apetrei

This study evaluates a tetravalent SARS-CoV-2 S1 subunit vaccine in SIV-infected rhesus macaques, showing robust humoral and cellular immune responses, including cross-reactivity against Omicron.

bioRxiv · Mar 15, 2023Immunology

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

E. Kim, M. S. Khan, A. Ferrari, S. Huang, J. C. Sammartino, E. Percivalle, T. W. Kenniston, I. Cassaniti, F. Baldanti, A. Gambotto

This study shows that a S1 subunit booster vaccine enhances neutralizing antibodies and cross-reactivity against multiple SARS-CoV-2 variants in aged mice vaccinated with an adenovirus-based vaccine.

bioRxiv · Oct 25, 2022Microbiology

Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein

M. S. Khan, E. Kim, A. McPherson, F. J. Weisel, S. Huang, T. W. Kenniston, E. Percivalle, I. Cassaniti, F. Baldanti, M. Meisel, A. Gambotto

This paper develops a novel adenovirus-vectored SARS-CoV-2 vaccine expressing S1-N fusion protein, showing improved immunogenicity in mice against SARS-CoV-2 variants.

bioRxiv · May 9, 2022Immunology

Immunity to SARS-CoV-2 up to 15 months after infection

H. Marcotte, A. Piralla, F. Zuo, L. Du, I. Cassaniti, H. Wan, M. Kumagai-Braesh, J. Andrell, E. Percivalle, J. C. Sammartino, Y. Wang, S. Vlachiotis, J. Attevall, F. Bergami, A. Ferrari, , Q. Pan-Hammarstrom

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

bioRxiv · Oct 8, 2021Immunology

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

R. De Gasparo, M. Pedotti, L. Simonelli, P. Nickl, F. Muecksch, I. Cassaniti, E. Percivalle, J. C. C. Lorenzi, F. Mazzola, D. Magri, T. Michalcikova, J. Haviernik, V. Honig, B. Mrazkova, N. Polakova, , T. Hatziioannou

bioRxiv · Jan 22, 2021 · PreprintImmunology

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

N. Sherina, A. Piralla, L. Du, H. Wan, M. Kumagai-Braesh, J. Andrell, S. Braesch-Andersen, I. Cassaniti, E. Percivalle, A. Sarasini, F. Bergami, R. Di Martino, M. Colaneri, M. Vecchia, M. Sambo, , Q. Pan-Hammarstrom

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

bioRxiv · Nov 6, 2020 · PreprintImmunology