Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse
H. Nomura, N. Wada, H. Takahashi, Y. Kase, J. Yamagami, S. Egami, H. Iriki, M. Mukai, A. Kamata, H. Ito, H. Fujii, T. Ishikura, H. Koseki, T. Watanabe, T. Yamada, , M. Amagai
This study shows that inhibiting immunoglobulin class-switching prevents pemphigus onset in mice, with FcγRIIB signaling attenuation contributing to disease.
bioRxiv · May 23, 2021 · PreprintImmunology