T. Yamada

DNA-free and genotype-independent CRISPR/Cas9 system in soybean

This paper develops a DNA-free CRISPR/Cas9 system in soybean using iPB-RNP method, achieving genome editing in shoot apical meristems without tissue culture, resulting in 0.4-4.6% mutation transmission to next generation.

Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence

This study identifies Cdc42 and Rac GTPase inhibition as a strategy to block hyphal elongation and virulence in Trichophyton rubrum, with EHop-016 showing promise as an antifungal lead.

Discovering and exploring the hidden diversity of human gut viruses using highly enriched virome samples

The paper presents a method to discover new human gut viruses using enriched virome samples and reports over 162,000 novel viral sequences.

Cell-state plasticity drives heterogeneity in Group 3/4 medulloblastoma

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

The Ptk2-Pma1 pathway enhances tolerance to terbinafine in Trichophyton rubrum

This study identifies the TrPtk2-TrPma1 pathway in Trichophyton rubrum as critical for terbinafine tolerance and suggests it as a target for antifungal therapy.

Neonicotinoids and Varroa mites force the extending of longevity in a bee colony during overwintering to forget

The paper uses a mathematical model to show that neonicotinoids and Varroa mites disrupt the seasonal extension of bee colony longevity during overwintering.

Decoupling of the Onset of Anharmonicity between a Protein and Its Surface Water around 200 K

The paper investigates the onset of anharmonicity in a protein and its surface water around 200 K, finding they are decoupled, with the protein's transition being intrinsic and the water's being a resolution effect.

Improved Protein Model in SPICA Force Field

This paper improves the SPICA force field to better simulate proteins, including IDPs and peripheral proteins, by introducing secondary structure-dependent nonbonded parameters and re-optimizing interactions.

Evaluation of the appropriateness of pesticide administration-concentrations to honey bee Apis mellifera colony in long-term field experiments and modest proposal

The paper evaluates pesticide concentrations administered to honey bee colonies in field experiments and proposes guidelines for appropriate dosing based on intake data.

Relationship between salmon egg subsidy and the distribution of an avian predator

The paper examines how salmon egg availability affects brown dipper abundance and distribution, finding a strong correlation with spawning redds.

Charge neutralization and β-elimination cleavage mechanism of family 42 L-rhamnose-α-1,4-D-glucuronate lyase revealed using neutron crystallography

This paper uses neutron crystallography to reveal the charge neutralization and β-elimination mechanism of FoRham1, an enzyme that cleaves gum arabic.

Structure of a LRRC8 chimera with physiologically relevant properties reveals heptameric assembly and pore-blocking lipids

The paper describes a LRRC8 chimera with physiologically relevant properties, revealing a heptameric structure and the role of membrane lipids in channel function.

A method for identifying environmental stimuli and genes responsible for genotype-by-environment interactions from a large-scale multi-environment data set

This paper introduces a method to identify environmental stimuli and genes involved in genotype-by-environment interactions using large-scale multi-environment data.

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse

This study shows that inhibiting immunoglobulin class-switching prevents pemphigus onset in mice, with FcγRIIB signaling attenuation contributing to disease.

Oxicam-type NSAIDs enhance Agrobacterium-mediated transformation in plants

This study shows oxicam-type NSAIDs like tenoxicam enhance Agrobacterium-mediated transformation in plants by temporarily suppressing immune responses, improving both transient and stable transformation efficiency.

Manage flowering time in Miscanthus and sugarcane to facilitate intra- and intergeneric crosses

This study investigates how day length affects flowering time in Miscanthus and sugarcane to enable synchronized hybridization, finding that day length requirements vary by species and geographic origin.

Distinct transcriptional programs of SOX2 in different types of small cell lung cancers

This study identifies distinct SOX2 transcriptional programs in different SCLC subtypes and highlights the therapeutic potential of targeting the ASCL1-SOX2 axis in classical SCLC.

A space-saving visual screening method, Glycine max FAST, for generating transgenic soybean

This paper introduces a space-saving visual screening method, GmFAST, for transgenic soybean development, which identifies homozygous lines with increased seed yield and oil production.

Translocational unfolding in clostridial binary iota toxin complex

This study reports the structure of the clostridial binary toxin translocation channel and its complex with ADP-ribosyltransferase, revealing a novel mechanism of N-terminal unfolding for protein translocation.

Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

This study identifies mucin O-glycans as a fermentation substrate for n-butyrate production, which supports immune homeostasis in the gut.

Clearance of senescent decidual cells by uterine natural killer cells drives endometrial remodeling during the window of implantation