H. Takahashi

SLC-25A46 Regulates Mitochondrial Fusion through FZO-1/Mitofusin and is Essential for Maintaining Neuronal Morphology

This study identifies SLC-25A46 as a regulator of mitochondrial fusion through FZO-1/Mitofusin and shows its role in maintaining neuronal morphology.

HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins

This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.

Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs and autoimmune type 1 diabetes

This study shows Tyk2 inhibition reduces autoimmune T1D in NOD mice by impairing CD8+ CTL development and {beta}-cell inflammation.

Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.

Single-cell transcriptomic analysis of pea shoot development and cell-type-specific responses to boron deficiency

This study uses single-cell RNA sequencing to analyze pea shoot development and cell-type-specific responses to boron deficiency, revealing differential gene expression and developmental impacts.

Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3

This study generates functional and long-lived melanocytes from human pluripotent stem cells using transient JMJD3 expression, showing melanogenesis and engraftability in mice.

Raman spectral analysis of microbial pigment compositions in vegetative cells and heterocysts of multicellular cyanobacterium

This study uses Raman spectroscopy to analyze pigment composition changes in differentiated and undifferentiated cells of Anabaena sp. PCC 7120, revealing differences in phycobilisome decomposition between cell types.

Identification of basic helix-loop-helix transcription factors that activate betulinic acid biosynthesis by RNA-sequencing of hydroponically cultured Lotus japonicus

The paper identifies LjbHLH32 and LjbHLH50 as transcription factors that activate betulinic acid biosynthesis in Lotus japonicus through RNA-sequencing and functional experiments.

DOTA chelation through click chemistry enables favorable biodistribution of 89Zr-radiolabeled antibodies: A comparison with DFO chelation

This paper compares the biodistribution of 89Zr-labeled antibodies conjugated with DOTA versus DFO chelators, finding that DOTA chelation via click chemistry provides better biodistribution profiles.

Structure of a LRRC8 chimera with physiologically relevant properties reveals heptameric assembly and pore-blocking lipids

The paper describes a LRRC8 chimera with physiologically relevant properties, revealing a heptameric structure and the role of membrane lipids in channel function.

Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance

The paper shows that glutamine synthetase mRNA produces an sRNA, GlnZ, which regulates carbon/nitrogen metabolism by repressing SucA expression.

Genetic architectures of postmating isolation and morphology of two highly diverged rockfishes (genus Sebastes)

This study investigates the genetic basis of postmating isolation and morphology in two rockfish species, identifying QTLs and genes associated with reproductive isolation and color patterns.

OTUD1 deubiquitylase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

This study identifies OTUD1 as a deubiquitylase that suppresses NF-κB and KEAP1-mediated inflammatory and oxidative stress responses, while promoting antiviral pathways and ROS-associated cell death.

Structural basis for activation and gating of IP3 receptors

The paper reports cryo-EM structures of human IP3R3 in different gating states, revealing the molecular mechanisms of activation and inhibition by IP3, Ca2+, and ATP.

Time-series Multi-spectral Imaging in Soybean for Improving Biomass and Genomic Prediction Accuracy

This study uses multi-spectral imaging to predict soybean biomass by analyzing growth stages and irrigation effects on genomic and phenotypic accuracy.

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouse

This study shows that inhibiting immunoglobulin class-switching prevents pemphigus onset in mice, with FcγRIIB signaling attenuation contributing to disease.

Intimate genetic relationships and fungicide resistance in multiple strains of human pathogenic fungus Aspergillus fumigatus isolated from a plant bulb

The paper analyzes genetic relationships and fungicide resistance in azole-resistant Aspergillus fumigatus strains isolated from a tulip bulb, revealing genetic recombination and resistance to multiple fungicide classes.

On-site genomic epidemiological analysis of antimicrobial-resistant bacteria in Cambodia with portable laboratory equipment

This study uses portable lab equipment to analyze antimicrobial-resistant bacteria in Cambodia, identifying specific resistance genes and their plasmid locations.

Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole

Transcriptome signature in E. coli under a prolonged starvation environment

This study identifies transcriptome changes in E. coli during long-term starvation, revealing common and distinct gene expression patterns compared to short-term stationary phase.

PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide

The paper identifies PLZF as a CRBN substrate degraded by thalidomide and 5-hydroxythalidomide, linking it to teratogenesis.

Direct detection of mRNA expression in microbial cells by fluorescence in situ hybridization using RNase H-assisted rolling circle amplification

This paper develops a FISH method to directly detect mRNA in microbial cells at the single-cell level without reverse transcription, applicable to both gram-negative and gram-positive microbes.

Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression

This study shows that combining anti-CD137 mAb with trastuzumab enhances NK cell-mediated ADCC against HER2-low pancreatic cancer cells, particularly in individuals with FcγRIIIA-VV/VF genotype.