Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy
S. Syga, H. P. Jain, M. Krellner, H. Hatzikirou, A. Deutsch
This paper investigates how somatic evolution and phenotypic plasticity interact in glioblastoma, showing that phenotypic heterogeneity, not genetic diversity, better predicts poor treatment outcomes.
PLOS Computational Biology · Aug 9, 2024Peer-reviewedCancer Biology