Author

H. Hatzikirou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:human· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

A. Barua· 3 shared P. Mascheroni· 3 shared M. Meyer-Hermann· 2 shared A. A. Pujar· 1 shared A. Beygi· 1 shared A. Deutsch· 1 shared A. Prunet· 1 shared C. Barentin· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersBiophysics

A. Barua

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Author profile →

8 papers

Recent·Most cited

Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy

S. Syga, H. P. Jain, M. Krellner, H. Hatzikirou, A. Deutsch

This paper investigates how somatic evolution and phenotypic plasticity interact in glioblastoma, showing that phenotypic heterogeneity, not genetic diversity, better predicts poor treatment outcomes.

PLOS Computational Biology · Aug 9, 2024Peer-reviewedCancer Biology

Lattice-based microenvironmental uncertainty driven phenotypic decision-making: a comparison with Notch-Delta-Jagged signaling

A. A. Pujar, A. Barua, D. Singh, U. Roy, M. K. Jolly, H. Hatzikirou

The paper develops a lattice-based agent model driven by microenvironmental uncertainty to study multicellular phenotypic decision-making, comparing it with Notch-Delta-Jagged signaling.

bioRxiv · Nov 16, 2021 · PreprintBiophysics

Close to optimal cell sensing ensures the robustness of tissue differentiation process: the avian photoreceptor mosaic case

A. Barua, A. Beygi, H. Hatzikirou

The paper develops a theory of stochastic thermodynamics for cell differentiation and applies it to avian photoreceptor mosaic data to show that optimal cell sensing ensures tissue differentiation robustness.

bioRxiv · Feb 14, 2021Biophysics

Investigating the physical effects in bacterial therapies for avascular tumors

P. Mascheroni, M. Meyer-Hermann, H. Hatzikirou

This study develops a mathematical model to analyze how physical effects, such as bacterial chemotaxis and killing rates, influence the effectiveness of bacterial therapy in avascular tumors.

bioRxiv · Feb 21, 2020Biophysics

Mechanical-control of cell proliferation increases resistance to chemotherapeutic agents

I. Rizzuti, P. Mascheroni, S. Arcucci, Z. Ben-Meriem, A. Prunet, C. Barentin, C. Riviere, H. Delanoe-Ayari, H. Hatzikirou, J. Guillermet-Guibert, M. Delarue

The paper shows that compressive stress in pancreatic cancer spheroids reduces chemotherapeutic efficacy by decreasing cell proliferation.

bioRxiv · Jan 18, 2020Cancer Biology

A least microenvironmental uncertainty principle (LEUP) as a generative model of collective cell migration mechanisms.

A. Barua, J. M. Navas Sedeno, H. Hatzikirou

This paper introduces the LEUP model to generate collective cell migration patterns without full mechanistic details, demonstrating its applicability to bacterial swarming behavior.

bioRxiv · Oct 4, 2019Biophysics

On the impact of chemo-mechanically induced phenotypic transitions in gliomas

P. Mascheroni, J. C. Lopez Alfonso, M. Kalli, T. Stylianopoulos, M. Meyer-Hermann, H. Hatzikirou

This study examines how mechanical compression affects glioma cell migration and proliferation, and develops a model showing a trade-off between tumor infiltration and cellular content in response to stress-alleviation strategies.

bioRxiv · Dec 6, 2018Biophysics

Hook-length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle

I. Spöring, V. A. Martinez, C. Hotz, J. Schwarz-Linek, K. L. Grady, J. M. Nava-Sedeno, T. Vissers, H. M. Singer, M. Rohde, C. Bourquin, H. Hatzikirou, W. C. Poon, Y. Dufour, M. Erhardt

This study shows that the optimal hook-length in Salmonella enterica maximizes flagellar bundle stability and motility efficiency.

bioRxiv · Jul 31, 2018Microbiology