S. Syga

Evolution of phenotypic plasticity leads to tumor heterogeneity with implications for therapy

This paper investigates how somatic evolution and phenotypic plasticity interact in glioblastoma, showing that phenotypic heterogeneity, not genetic diversity, better predicts poor treatment outcomes.

Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning

This study shows that matrix density and guidance cues determine whether cancer cells use proteolytic or non-proteolytic invasion strategies in 3D tissue.