Author

H. R. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. C. Kruse· 2 shared D. A. Greenfield· 1 shared P. Sliz· 1 shared R. M. Betz· 1 shared R. O. Dror· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. C. Kruse

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2 papers

Recent·Most cited

Virtual screening identifies novel high-affinity σ1 receptor ligands

H. R. Schmidt, D. A. Greenfield, P. Sliz, A. C. Kruse

The paper uses virtual screening to identify novel high-affinity σ1 receptor ligands, finding 77% of tested compounds bind with high affinity.

bioRxiv · Jul 16, 2019 · PreprintPharmacology & Toxicology

Structural basis for sigma-1 receptor ligand recognition

H. R. Schmidt, R. M. Betz, R. O. Dror, A. C. Kruse

This study presents crystal structures and MD simulations of the sigma-1 receptor bound to ligands, revealing agonist-induced structural changes and a multistep binding mechanism.

Nature Structural & Molecular Biology · Oct 5, 2018Peer-reviewedPharmacology & Toxicology