Author

H. S. Kwok

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

D. Soll· 2 shared S. V. Melnikov· 2 shared A. L. Waterbury· 1 shared A. M. Freedy· 1 shared A. P. Siegenfeld· 1 shared A. van den Elzen· 1 shared B. Liau· 1 shared C. C. Thoreen· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersEvolutionary Biology

D. Soll

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma

H. S. Kwok, A. M. Freedy, A. P. Siegenfeld, J. W. Morriss, A. L. Waterbury, S. M. Kissler, B. Liau

The paper identifies drug addiction mutations in EZH2-mutant lymphoma that reveal a methylation ceiling, showing how inhibiting SETD2 can block lymphoma growth.

bioRxiv · Apr 4, 2022Cancer Biology

Exploiting evolutionary trade-offs to combat antibiotic resistance

S. V. Melnikov, D. L. Stevens, X. Fu, H. S. Kwok, J.-T. Zhang, Y. Shen, J. Sabina, K. Lee, H. Lee, D. Soll

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

bioRxiv · Jan 20, 2020 · PreprintEvolutionary Biology

Archaeal ribosomal proteins possess nuclear localization signal-type motifs: implications for the origin of the cell nucleus

S. V. Melnikov, H. S. Kwok, K. Manakongtreecheep, A. van den Elzen, C. C. Thoreen, D. Soll

The paper identifies NLS-type motifs in archaeal ribosomal proteins, showing they can functionally substitute eukaryotic NLSs and suggesting NLSs predate the nucleus.

bioRxiv · Jun 14, 2019Evolutionary Biology