Author

J.-T. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

N. Cui· 2 shared N. Jia· 2 shared C. Wang· 1 shared D. L. Stevens· 1 shared D. Soll· 1 shared H. Huang· 1 shared H. Lee· 1 shared H. S. Kwok· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

N. Cui

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for ssDNA-activated NADase activity of the prokaryotic SPARTA immune system

J.-T. Zhang, X.-Y. WeiWei, N. Cui, R. Tian, N. Jia

The paper determines the structure of the SPARTA immune system, revealing how it activates NADase activity in response to ssDNA targets.

bioRxiv · Jul 14, 2023 · PreprintBiochemistry

Structural rearrangements of a caspase-like protease TPR-CHAT govern virus-host discrimination during type III-E CRISPR-Caspase immunity

N. Cui, J.-T. Zhang, Z. Li, X.-Y. Liu, C. Wang, H. Huang, N. Jia

The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.

bioRxiv · Sep 3, 2022Biochemistry

Exploiting evolutionary trade-offs to combat antibiotic resistance

S. V. Melnikov, D. L. Stevens, X. Fu, H. S. Kwok, J.-T. Zhang, Y. Shen, J. Sabina, K. Lee, H. Lee, D. Soll

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

bioRxiv · Jan 20, 2020 · PreprintEvolutionary Biology