Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis
H. N. Nemade, D. Mehrkens, H. S. Lottermoser, Z. E. Yilmaz, P. Schelemei, F. R. Picard, S. Geissen, G. F. Schwab, F. F. Hoyer, H. Guthoff, A. Hof, F. S. Nettersheim, A. Sachinidis, H. Winkels, S. Baldus, , M. Mollenhauer
This study shows that inhibiting MLKL reduces abdominal aortic aneurysm development by preventing smooth muscle cell necroptosis and associated inflammation.
bioRxiv · Nov 24, 2022Cell Biology