D. Mehrkens

Vascular ultrasound for in vivo assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm

This study uses high-resolution ultrasound to assess arterial pathologies in atherosclerosis and aortic aneurysm mouse models, finding correlations between ultrasound metrics and histological changes.

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

Inhibition of myeloperoxidase prevents thoracic aortic aneurysm formation in Marfan mice

This study shows that inhibiting myeloperoxidase prevents thoracic aortic aneurysms in Marfan mice by reducing inflammation and extracellular matrix damage.

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

This study shows that inhibiting MLKL reduces abdominal aortic aneurysm development by preventing smooth muscle cell necroptosis and associated inflammation.