H. Winkels

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

This study uses scRNA TCR and BCR sequencing to analyze T and B cell responses in murine AAA, finding no clonal expansion of TCRs or BCRs.

Pentose Phosphate Pathway Inhibition activates Macrophages towards phagocytic Lymphoma Cell Clearance

This study shows that inhibiting the pentose phosphate pathway enhances macrophage phagocytosis of lymphoma cells and improves survival in a mouse model.

Vascular ultrasound for in vivo assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm

This study uses high-resolution ultrasound to assess arterial pathologies in atherosclerosis and aortic aneurysm mouse models, finding correlations between ultrasound metrics and histological changes.

Inhibition of myeloperoxidase prevents thoracic aortic aneurysm formation in Marfan mice

This study shows that inhibiting myeloperoxidase prevents thoracic aortic aneurysms in Marfan mice by reducing inflammation and extracellular matrix damage.

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

This study shows that inhibiting MLKL reduces abdominal aortic aneurysm development by preventing smooth muscle cell necroptosis and associated inflammation.