Author

H. Shuman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

E. M. Ostap· 2 shared A. Snoberger· 1 shared B. Barua· 1 shared D. A. Winkelmann· 1 shared E. Forgacs· 1 shared J. L. Atherton· 1 shared S. Pyrpassopoulos· 1 shared Y. E. Goldman· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

E. M. Ostap

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2 papers

Recent·Most cited

Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil

A. Snoberger, B. Barua, J. L. Atherton, H. Shuman, E. Forgacs, Y. E. Goldman, D. A. Winkelmann, E. M. Ostap

This study shows that the HCM mutation R712L in β-cardiac myosin reduces the working stroke, which is reversed by the drug omecamtiv mecarbil.

bioRxiv · Oct 2, 2020Biophysics

Modulation of kinesin’s load-bearing capacity by force geometry and the microtubule track

S. Pyrpassopoulos, H. Shuman, E. M. Ostap

This study shows that kinesin's attachment duration to microtubules varies significantly based on force geometry, with parallel forces increasing attachment time up to 10-fold compared to vertical forces.

bioRxiv · Aug 21, 2019Biophysics