Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil
A. Snoberger, B. Barua, J. L. Atherton, H. Shuman, E. Forgacs, Y. E. Goldman, D. A. Winkelmann, E. M. Ostap
This study shows that the HCM mutation R712L in β-cardiac myosin reduces the working stroke, which is reversed by the drug omecamtiv mecarbil.
bioRxiv · Oct 2, 2020Biophysics