Author

H. Steel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Papachristodoulou· 2 shared J. James· 2 shared S. Towers· 2 shared B. Geddes· 1 shared B. Norton-Baker· 1 shared C. Kelly· 1 shared G. A. Hood· 1 shared G. Abrahams· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

A. Papachristodoulou

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Author profile →

6 papers

Recent·Most cited

Optimised control of adaptive evolution with competing selective pressures

M. Corrao, G. Abrahams, H. Steel

This paper develops optimal control strategies for microbial evolution by manipulating selective pressures to maximize adaptation rates, supported by simulations and experimental data.

bioRxiv · Apr 8, 2024 · PreprintEvolutionary Biology

Optimisation strategies for directed evolution without sequencing

J. James, S. Towers, J. Foerster, H. Steel

This paper develops selection strategies for directed evolution without sequencing, showing they can increase the probability of finding the global fitness peak by up to 7.5 fold.

bioRxiv · Mar 18, 2024 · PreprintBioengineering

Integration of pH control into Chi.Bio reactors and demonstration with small-scale enzymatic poly(ethylene terephthalate) hydrolysis

M. C. Denton, N. P. Murphy, B. Norton-Baker, M. Lua, H. Steel, G. T. Beckham

The paper enhances the Chi.Bio bioreactor with pH control, demonstrating its effectiveness in PET hydrolysis with reduced enzyme requirements.

bioRxiv · Mar 3, 2024Bioengineering

Learning-Based Estimation of Fitness Landscape Ruggedness for Directed Evolution

S. Towers, J. James, H. Steel, I. Kempf

This paper introduces a learning-based method to estimate fitness landscape ruggedness during directed evolution using population average performance data, improving experimental outcomes.

bioRxiv · Feb 28, 2024 · PreprintBioengineering

A multi-sensor system provides spatiotemporal oxygen regulation of gene expression in a Rhizobium-legume symbiosis

P. S. Poole, P. J. Rutten, H. Steel, G. A. Hood, L. McMurtry, B. Geddes, A. Papachristodoulou

The paper investigates oxygen regulation of gene expression in Rhizobium-legume symbiosis, showing FnrN is key for nitrogen fixation with hFixL-FxkR-FixK priming its expression.

bioRxiv · Sep 9, 2020Microbiology

Chi.Bio: An open-source automated experimental platform for biological science research

H. Steel, R. Habgood, C. Kelly, A. Papachristodoulou

Chi.Bio is an open-source platform that automates biological experiments by integrating multiple functions into a single system for in situ control and measurement of cell cultures.

bioRxiv · Oct 7, 2019 · PreprintBioengineering