C. Kelly

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single cell RNA sequencing study to understand age-related macular degeneration

This study uses single-cell RNA sequencing to examine how zinc supplementation affects the transcriptome of human retinal pigment epithelial cells, identifying genes and pathways involved in AMD-related processes.

Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel

Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma

This study identifies inflammation-induced loss of CFTR-expressing ionocytes in non-eosinophilic asthma using single-cell RNA-seq and confirms it in human and murine models.

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

This study investigates Fxr signaling and microbial bile salt metabolism in zebrafish intestines, revealing conserved pathways and Fxr roles in transcriptional programs.

Impact of industrial production system parameters on chicken microbiomes: mechanisms to improve performance and reduce Campylobacter

This study examines how industrial chicken production system parameters affect gut microbiome composition and Campylobacter presence, identifying links between environmental factors, microbial dynamics, and performance metrics.

Chi.Bio: An open-source automated experimental platform for biological science research

Chi.Bio is an open-source platform that automates biological experiments by integrating multiple functions into a single system for in situ control and measurement of cell cultures.

Olfactory sensory neurons mediate ultra-rapid antiviral immune responses in teleosts in a TrkA-dependent manner

This study shows that olfactory sensory neurons in teleosts detect viruses via TrkA receptor interaction, triggering local immune responses and reducing systemic inflammation.

Comprehensive longitudinal microbiome analysis of the chicken cecum reveals a shift from competitive to environmental drivers and a window of opportunity for Campylobacter

This study tracks the chicken cecum microbiome from day 3 to 35, identifying a shift in microbial drivers and a window for Campylobacter appearance.

The chemokine receptor CXCR2 contributes to murine adipocyte development

This study shows that CXCR2 deficiency in mice leads to reduced subcutaneous adipose tissue due to smaller adipocytes, primarily in females.