Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma
R. Yoshitake, K. Saeki, S. Eto, M. Shinada, R. Nakano, H. Sugiya, Y. Endo, N. Fujita, R. Nishimura, T. Nakagawa
This study shows that BRAF mutation activates the RAF/MEK/ERK pathway, leading to COX2 overexpression and PGE2 production in canine urothelial carcinoma, promoting inflammation.
bioRxiv · Oct 1, 2019Cancer Biology