Y. Endo

Liver-specific LXR inhibition represses reverse cholesterol transport in cholesterol-fed mice

This study shows that liver-specific LXR inhibition reduces HDL levels and reverse cholesterol transport in cholesterol-fed mice by decreasing LXR-target gene expression.

Universal pretreatment development for low-input proteomics using Lauryl Maltose Neopentyl Glycol

The paper develops a low-input proteomics method called LASP to improve peptide recovery and reduce MS contamination, achieving 1,175 proteins identified per single cell.

Generation of iPSCs from endangered Grevy's zebra and comparative transcriptomic analysis of mammalian PSCs

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

Quantitative modeling of regular retinal microglia distribution

The paper quantitatively analyzes microglia distribution regularity, formulates a mathematical model, and identifies direct cell-cell contact as the key factor in generating regular spacing.

Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells

This study evaluates the efficacy of mesenchymal stem cells derived from Werner syndrome-induced pluripotent stem cells in treating skin ulcers, finding reduced angiogenic potential and improved healing with VEGF supplementation.

Aberrant claudin-6-adhesion signal promotes endometrial cancer progression via estrogen receptor α

The paper shows that CLDN6 promotes endometrial cancer progression by activating estrogen receptor α through SFK/PI3K signaling, independent of ligand.

Genetic signatures of evolution of the pluripotency gene regulating network across mammals

The paper analyzes the evolution of the pluripotency gene regulatory network across mammals, finding conservation in signaling pathways and rapid evolution in downstream targets.

Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma

This study shows that BRAF mutation activates the RAF/MEK/ERK pathway, leading to COX2 overexpression and PGE2 production in canine urothelial carcinoma, promoting inflammation.

Genetic Signatures of Lipid Metabolism Evolution in Cetacea

This study identifies 18 positively selected genes in cetaceans related to lipid metabolism, showing divergent evolution from bovids and highlighting pathways involved in lipid digestion and energy production.