T. Nakagawa

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

TANK binding kinase 1 promotes BACH1 degradation through both phosphorylation-dependent and -independent mechanisms without relying on heme and FBXO22

Drinking-Water 4,4'-Methylenedianiline Establishes a Longitudinally Tractable Mouse Model of Cholestatic Liver Injury

This paper develops a drinking-water model of cholestatic liver injury in mice using MDA, showing sustained ALT elevation and distinct histological and biochemical features compared to TAA-DW.

Genetic and transcriptomic dissection of nitrate-independent function of Arabidopsis NRT1.1/NPF6.3/CHL1 under high ammonium condition

This study investigates the nitrate-independent role of NRT1.1 in Arabidopsis under high ammonium conditions, finding that its plasma membrane localization affects ammonium tolerance through gene expression changes.

Dimension reduction of microbiome data linked Bifidobacterium to allergic rhinitis

The paper applies dimension reduction methods to microbiome data and links Bifidobacterium to allergic rhinitis risk and nutrient intake.

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

Scale space calibrates present and subsequent spatial learning in Barnes maze in mice

This study shows that spatial learning in mice is influenced by the scale of the Barnes maze, with larger scale spaces requiring more computational resources and prior learning in larger scales facilitating subsequent learning in smaller scales.

A dark matter in sake brewing: Origin of microbes producing a Kimoto-style fermentation starter

This study identifies the microbial sources in Kimoto-style sake fermentation by analyzing environmental samples and fermentation starters.

A unique case in which Kimoto-style fermentation was completed with Leuconostoc as the dominant genus without transitioning to Lactobacillus.

The paper characterizes a unique Kimoto-style fermentation process where Leuconostoc dominates without transitioning to Lactobacillus, differing from previously reported microbial patterns.

Root-specific activation of plasma membrane H+-ATPase 1 enhances plant growth and shoot accumulation of nutrient elements under nutrient-poor conditions in Arabidopsis thaliana

This study shows that root-specific activation of PM H+-ATPase in Arabidopsis improves growth and nutrient uptake under poor conditions without affecting stomatal function.

Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study

The study identifies four nutrients and two gut microbiome genera associated with reduced risk of allergic rhinitis, with an interaction between retinol and Prevotella.

Root-specific reduction of cytokinin perception enhances shoot growth with an alteration of trans-zeatin distribution in Arabidopsis thaliana

This study shows that reducing cytokinin perception in roots increases shoot growth by altering trans-zeatin distribution in Arabidopsis.

An ancestral function of strigolactones as symbiotic rhizosphere signals

This study identifies BSB, an ancestral strigolactone in bryophytes, which functions as a rhizosphere signal for AM symbiosis and was later co-opted as a plant hormone.

CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer

The paper shows that blocking CCR4 reduces Treg infiltration and improves survival in a canine model of advanced prostate cancer.

Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target

This study identifies Matriptase cleavage of Podocin as a mechanism of podocyte injury in CKD, suggesting Matriptase inhibition as a therapeutic strategy.

Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

The paper identifies 27-hydroxycholesterol's role in regulating URAT1/SLC22A12 gene expression through estrogen response elements, linking cholesterol metabolism to serum uric acid levels.

Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma

This study shows that BRAF mutation activates the RAF/MEK/ERK pathway, leading to COX2 overexpression and PGE2 production in canine urothelial carcinoma, promoting inflammation.

The Effect of Eucalyptol on Nursing Home Residents

This pilot study investigates eucalyptol's effect on dementia symptoms in nursing home residents, finding significant improvements in cognitive and behavioral scores with increased exposure.

Mammalian retromer is an adaptable scaffold for cargo sorting from endosomes

This study identifies adaptable retromer structures and their role in cargo sorting from endosomes to the TGN or plasma membrane in mammals.

Sufficient therapeutic effect of cryopreserved frozen adipose-derived regenerative cells on burn wounds

This study shows that cryopreserved adipose-derived regenerative cells (ADRCs) are as effective as fresh ADRCs in promoting burn wound healing.