Conditional deletion of CEACAM1 causes hepatic stellate cell activation
H. T. Muturi, H. E. Ghadieh, S. Asalla, S. G. Lester, S. Verhulst, H. L. Stankus, S. Zaidi, R. Abdolahipour, G. D. Belew, L. A. v. Grunsven, S. L. Friedman, R. F. Schwabe, T. D. Hinds, S. M. Najjar
This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.
bioRxiv · Apr 2, 2024 · PreprintPhysiology